- Authors: Facco FL, et al.
- Journal: Journal of Clinical Sleep Medicine
- Additional Resource: eScholarship
- Key Finding: Pregnant patients with sleep disordered breathing had significantly higher risk of hypertensive disorders including preeclampsia and gestational diabetes, with risk increasing by severity (dose-response relationship).
Implications of sleep-disordered breathing in pregnancy
- Journal: American Journal of Obstetrics and Gynecology
- Key Finding: Narrative review linking sleep disordered breathing with adverse maternal outcomes, particularly preeclampsia. Highlights inflammation, oxidative stress, and sympathetic activation as shared mechanisms.
- Authors: Izci-Balserak B, Pien GW
- Journal: Sleep Medicine Clinics
- Key Finding: Outlines biological mechanisms including intermittent hypoxia, endothelial dysfunction, systemic inflammation, and altered placental perfusion that overlap with preeclampsia pathophysiology.
Association Between Sleep Disorders and Preeclampsia: Systematic Review and Meta-analysis
- Key Finding: Meta-analysis demonstrating obstructive sleep apnea is associated with significantly increased preeclampsia risk. Concludes sleep disordered breathing should be considered an independent risk factor requiring screening.
Association Between Sleep Disordered Breathing During Pregnancy and Maternal and Fetal Outcomes
- Journal: Frontiers in Neurology
- Key Finding: Reviews associations with adverse maternal outcomes (preeclampsia, gestational hypertension) and fetal consequences (growth restriction, preterm birth). Emphasizes neurologic and vascular pathways.
The Upper Airway in Pregnancy and Pre-Eclampsia
- Journal: American Thoracic Society
- Key Finding: Documents anatomic changes including increased airway edema, reduced caliber, and higher collapsibility during pregnancy, with more pronounced changes in preeclampsia patients.
CPAP Treatment and Hypertensive Adverse Outcomes in Pregnancy
- Journal: JAMA Network Open
- Key Finding: Randomized clinical trial showing CPAP treatment for OSA during pregnancy improved blood pressure control and reduced hypertensive adverse outcomes, supporting causal role and treatment benefit.
Treatment of Obstructive Sleep Apnea in High-Risk Pregnancy: Multicenter Randomized Controlled Trial
- Key Finding: Multicenter trial demonstrating CPAP therapy improvements in nocturnal oxygenation and blood pressure metrics in high-risk pregnant patients, supporting treatment to reduce preeclampsia-related morbidity.
Continuous Positive Airway Pressure for Sleep Apnea in Pregnancy (SLEEP Trial)
- Source: ClinicalTrials.gov
- Key Finding: Trial designed to evaluate whether CPAP improves maternal blood pressure, endothelial function, and pregnancy outcomes, reflecting recognition of sleep disordered breathing as modifiable preeclampsia risk factor.
- Journal: Australian and New Zealand Journal of Obstetrics and Gynaecology
- Key Finding: Systematic review showing CPAP improves sleep-related breathing parameters and may improve blood pressure control. Supports CPAP as safe and potentially beneficial therapy for hypertensive risk reduction.
